H2AX and Rotavirus infection: In this study, we aimed to determine the effects of HSP-27, Caspase-3, IL-2, γ-H2AX, HMGB-1, SP-D, and GDH on the pathogenesis of rotavirus infection by using biomarkers of lung and liver injury in neonatal diarrheic calves naturally infected with rotavirus, both in vivo and postmortem.