This is crucial as ribosome biogenesis is a key cellular process impaired by immunosuppressive PGE2-EP2/EP4 signaling in TME, and its preservation in these TAMs may provide the metabolic support for sustained cytokine and eicosanoid (including prostaglandin) production within the tumor microenvironment [18,19]. The gene discussed is PTGER2; the disease is neoplasm.