It is of particular importance that 37 of the 43 proteins are candidate biomarkers (CBs) of AD identified in other proteomic studies, and 19 of them were replicated in ≥3 independent cohorts (Table 1): APOE, APOA4, FGG, FGB, FGA, FN1, AFM, SERPINA3, TF, ORM1, SERPINA1, ALB, APOA1, HP, CFB, CFI, APOB, SERPINF1, and A1BG. The gene discussed is APOB; the disease is Alzheimer disease.