GLS and head and neck squamous cell carcinoma: In head and neck squamous cell carcinomas, Yang et al. supported the overexpression of GLS1 as a poor prognostic marker, while demonstrating that the inhibition of GLS1 with bis-2-(5-phenylacetamido-1, 3, 4-thiadiazol-2-yl) ethyl sulphide (BPTES), was associated with a reduced growth rate of tumours, highlighting the significance of glutaminolysis on the propagation of tumour cells [91].