Interestingly, the hypertrophic response in mice subjected to pressure overload is enhanced in adiponectin null mice through a mechanism associated with the enhanced activation of the prohypertrophic transcriptional factor myocyte enhancer factor-2 (Mef2), thus suggesting that background adiponectin is required for the induction of cardiac hypertrophy following induction of pressure overload [78]. The gene discussed is ADIPOQ; the disease is cardiac hypertrophy.