NF1 and left ventricular hypertrophy: This case represents the first reported instance of an NF1 patient harboring the novel NF1 c.2889_2893del (p.Q963Hfs*10) variant concurrently presenting with severe aortic regurgitation, valvular vegetations, left ventricular hypertrophy/enlargement, and left atrial dilation—manifestations not typically part of the natural history of NF1 [8,9].