NF1 and hemorrhage: It is important to note that NF1-related vasculopathy (e.g., renal/aortic stenosis, coronary artery aneurysms, or cerebrovascular abnormalities) [21,22,23] can not only directly cause organ ischemia or hemorrhage, but also significantly increase the risk of cardiovascular and cerebrovascular events by involving cardiac structures, increasing cardiac load, or inducing cerebrovascular circulatory disorders.