SERPINE1 and aortic valve insufficiency: We report the first case of a patient with neurofibromatosis type 1 (NF1) concurrently presenting with severe aortic regurgitation with valvular vegetations, left ventricular hypertrophy/enlargement, left atrial dilation, mitral regurgitation, and a PAI-1 4G/5G heterozygous genotype, ultimately leading to cerebral and splenic infarction.