Although GDF-15 circulates at low levels under normal physiological conditions, its serum concentration rises markedly in numerous chronic diseases—such as cardiovascular disorders, chronic kidney disease, malignancies, and infectious conditions—as well as in acute pathologies including myocardial infarction, pulmonary embolism, and trauma, similar to other acute-phase reactants [10,11]. This evidence concerns the gene GDF15 and cardiovascular disorder.