Immunohistochemical examination of tumor cells revealed positive reaction to AE1/AE3, CK20, protein (p)40 (Figure 3c), cytokeratin (CK)5/6 (Figure 3d), c-kit (Figure 3e), and neural cell adhesion molecule (NCAM)36 (Figure 3f) and negative reaction to GATA3, PSA, CK-7, CK-8, synaptophysin, and chromogranin A. A non-tumor lesion revealed very slight inflammation but no fibrosis in the portal area (Figure 3g). The gene discussed is KLK3; the disease is neoplasm.