The analysis revealed a statistically significant positive correlation between serum COMP levels and the degree of articular cartilage degradation in knee osteoarthritis (OA), as assessed by both USG (r = 0.61; p < 0.001) and MRI (r = 0.72; p < 0.001), indicating a strong correlation strength, as seen Table 9. The gene discussed is COMP; the disease is osteoarthritis, knee.