Our finding of elevated serum PLIN2 levels in NAFLD patients aligns with recent mechanistic evidence, particularly Fang et al. [41], who showed that exercise ameliorates hepatic lipid accumulation in a mouse NAFLD model by modulating the PLIN2-LIPA axis, a key regulator of lipophagy. This evidence concerns the gene PLIN2 and metabolic dysfunction-associated steatotic liver disease.