This effect may have been amplified by the higher cumulative glucocorticoid exposure in the tocilizumab group: corticosteroids upregulate S100A8/A9 transcription and stabilize its mRNA via IL-10 and Mitogen-Activated Protein Kinase (MAPK) signaling, promoting sustained calprotectin production even in the absence of active synovitis [22]. The gene discussed is S100A8; the disease is synovitis.