NKX2-5 and atrial fibrillation: As a result, nine loci were found to be significantly associated with PR intervals, of which five loci were also significantly associated with AF, including rs11047543 near SOX5 (51 kb 5′ of C12orf67), rs3807989 at intron 2 of CAV1/CAV2, rs11708996 at intron 14 of SCN5A, rs251253 next to NKX2-5 (3 kb 5′ of C5orf41), and rs6800541 at intron 14 of SCN10A [102].