SOX5 and atrial fibrillation: In the current research, two new SOX5 mutations linked to AF were discovered, including c.355C>T (p.Gln119*) locating at exon 3 and c.640G>T (p.Glu214*) locating at exon 5, hence were anticipated to produce truncating L-SOX5 proteins without HMG domain along with coiled-coil domain and fail to bind target promoters to transactivate downstream genes but have no effect on S-SOX5.