PITX2 and atrial fibrillation: Vogel et al. [105] examined the relationship between eight SNPs (located within or near the genes SOX5, KCNN3, CAV1, PITX2, KCNJ5, ZFHX3, and MYH7) and the risks of AF occurrence and recurrence in 259 AF patients and 108 control persons and revealed that the variation of rs11047543 near to SOX5 conferred a higher risk on the recurrence of AF after treatment with direct current cardioversion.