For example, a PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice showed that administering apigenin at a dose of 15 mg/kg reversed the changes in IL-6, TNF-α, and IL-1β, reducing their secretion by 27.3%, 29.8%, and 39.0%, respectively, while increasing IL-10 production by 58.1% and tyrosine hydroxylase (TH) immunopositive neurons by 37.1% [70]. This evidence concerns the gene IL1B and Parkinson disease.