GSR and brain ischemia: For instance, a study on cerebral ischemia–reperfusion (IR) induced in Wistar rats using the middle cerebral artery occlusion (MCAO) model and reperfusion, showed that pre-administration of rutin at a dose of 25 mg/kg significantly restored antioxidant enzymes glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) activities.