According to the best of our knowledge, this study provides the first comprehensive evaluation of CAPE-mediated modulation of cytokines (IL-8, IL-26, IL-10), PTX3, and metalloproteinases (MMP-1/-2/-3) in LPS- and/or IFN-α–stimulated CCF-STTG1 astrocytes, establishing an anti-glioma immunomodulatory potential of CAPE. Here, PTX3 is linked to central nervous system cancer.