BRAF and melanoma: It was shown that the antihypertensive drug telmisartan (AT1R antagonist and partial PPARγ agonist), but not losartan (pure AT1R antagonist), has a cytotoxic effect on BRAF V600E melanoma cells, as well as on cells resistant to a BRAF inhibitor, with the effect on mitochondrial integrity and on the induction of reactive oxygen species production [5].