Additionally, we sought to elucidate the underlying mechanisms of KAE’s synergistic and antiproliferative effects in colorectal carcinoma in a head-to-head approach with the reference drug cisplatin by tracking changes in the expression profiles of 42 key oncology-related proteins, including growth factors, cytokines, receptor tyrosine kinases, transcription factors, proteolytic enzymes, structure proteins and prognostic cancer biomarkers. The gene discussed is NTRK1; the disease is cancer.