PPIB and metabolic syndrome: For example, as shown in Figure 1C, a randomized single-blind crossover trial in individuals with metabolic syndrome (MetS)—a population at high risk for neurodegenerative diseases—evaluated the effects of a combined food product rich in high-oleic canola oil (HOCO)-DHA (providing 3 g/day DHA) and high-molecular-weight barley β-glucan (4.36 g/day) [32].