In summary, our study demonstrated that ALA might alleviate DCM by inhibiting ferroptosis through two mechanisms: inhibiting NCOA4-mediated ferritinophagy and activating the SLC7A11/GSH/GPX4 antioxidant axis, both of which are regulated by the AMPK-STAT3 signaling pathway. Here, STAT3 is linked to familial dilated cardiomyopathy.