Ferritinophagy-induced cell death has been implicated in cigarette smoke-induced chronic obstructive pulmonary disease (COPD) [54], apelin-13-induced cardiomyocyte hypertrophy [55], sepsis-induced cardiac injury [31], and zinc oxide nanoparticle-induced endothelial dysfunction [56]. This evidence concerns the gene APLN and chronic obstructive pulmonary disease.