Our findings provide evidence that CAEO activates executioner caspases; this aligns with previous studies on hepatocellular carcinoma [19] and glioblastoma [21] cells where CAEO regulated p53/p21 and CDK4/cyclin D1 protein expression and induced extrinsic and intrinsic apoptosis. The gene discussed is CDK4; the disease is hepatocellular carcinoma.