CASP3 and malignant colon neoplasm: Similar to the mitochondrial dysfunction and caspase-3/7 activation exhibited in A375 and HT-29 cells by our study, isoledene-rich plant fractions have been demonstrated to cause ROS generation, ΔΨm loss, cytochrome c release, and caspase-8/9/3 activation in HCT116 colon cancer cells [58].