Another important phlorotannin, octaphlorethol A (OPA) derived from Ishige foliaceae, inhibits melanin synthesis and tyrosinase activity through a cellular signalling cascade involving the suppression of MITF (microphthalmia-associated transcription factor), tyrosinase, and related proteins via the extracellular signal-regulated kinase (ERK) pathway in B16F10 melanoma cells [24]. Here, TYR is linked to melanoma.