Studies on anthocyanin-rich extracts from Aronia melanocarpa fruit have shown suppression of CRC cell growth via downregulation of Cyclin D1, activation of cell cycle inhibitors p21 and p27 and inhibition of PI3K/Akt and MAPK/ERK signaling cascades, which are critical for tumor cell survival and proliferation [55,61]. Here, AKT1 is linked to colorectal carcinoma.