While all phenotypes may present with obesity, it has been described that individuals with IGT often have reduced muscle insulin sensitivity, whereas individuals with IFG have low hepatic insulin sensitivity, such that studies show that IFG, IGT, and IFG + IGT are unique forms of glucose intolerance that promote CVD risk [4,5,6]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.