In addition, while xanthohumol reduces reactive oxygen species (ROS), it also improves motor deficits in 6-hydroxydopamine-induced Parkinsonian rodents [21,22], it decreases both the degeneration of spinal motoneurons and the progression of amyotrophic lateral sclerosis in superoxide dismutase 1 (Sod1) mutant animals [23]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.