The primary aim of this study was to evaluate the effects of daily consumption of a high-dose GTE supplement for one year on circulating levels of CRP, TNF-α, and IL-6 compared to placebo among postmenopausal women with overweight or obesity in a subset of the participants from the Minnesota Green Tea Trial (MGTT) [32]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.