HMWHA, beyond its well-established role as a structural component of the extracellular matrix, has demonstrated functional relevance in sustaining progesterone signaling—specifically through upregulation of PGRMC1, a non-classical progesterone receptor whose downregulation is associated with preterm labor and PPROM [56,57]. Here, PGRMC1 is linked to preterm premature rupture of the membranes.