In addition, Johanna et al. found that T2DM in older men was associated with PTGS2-mediated inflammation [36]; Yasmine et al. found that PTGS2-mediated inflammation may contribute to the development of T2DM in some individuals by examining the correlation between PTGS2 promoter variants and T2DM [37]. The gene discussed is PTGS2; the disease is type 2 diabetes mellitus.