In 2019, Mayer et al. introduced the concept of “non-IgE-mediated Allergic March”, suggesting that AD, asthma, and allergic rhinitis could co-exist in patients with non-IgE-mediated allergies, with an early peak of non-IgE-GI-FAs (including FPIAP) and AD in infancy and a subsequent development of asthma and allergic rhinitis from the time of school-age. The gene discussed is IGHE; the disease is Alzheimer disease.