In an experimental animal model, baicalin intravitreal injection reduced laser-induced choroidal neovascularization and vascular leakage in a dose-dependent manner, attenuating the up-regulation of VEGF, platelet-derived growth factor (PDGF), and matrix metalloproteinase-2 (MMP-2), suggesting its potential for treating exudative AMD [39]. The gene discussed is MMP2; the disease is age-related macular degeneration.