In chronic myeloid leukemia cells, curcumin inhibits HIF-α activity through the miR-22/IPO7/HIF-1α signaling axis, which synergistically downregulates the enzymatic activities of multiple glycolytic enzymes, pentose phosphate pathway enzymes, and HIF-1α target genes [40]. This evidence concerns the gene HIF1A and chronic myelogenous leukemia, BCR-ABL1 positive.