In prostate cancer cells, curcumin inhibits the activation of the ERK1/2/c-Myc/HIF-1α signaling axis and reduces the activity of rate-limiting enzymes such as HK1/2, PFKP, and PDH in a concentration-dependent manner, thereby blocking glycolytic metabolic flux and glucose consumption [26]. Here, HIF1A is linked to Familial prostate cancer.