In colon cancer cells, curcumin effectively blocks the release of arachidonic acid metabolites by inhibiting the phosphorylation of phospholipase A2 (cPLA2) and the activities of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) [72]. Here, PTGS2 is linked to malignant colon neoplasm.