In osteosarcoma MNNG/HOS/MG-63 cells and corresponding animal models, curcumin cooperatively regulates the Nrf2, SLC7A11, HO-1, and GPX4 signaling axis, resulting in abnormal accumulation of ROS and MDA, and the collapse of the GSH antioxidant system [123]. Here, HMOX1 is linked to osteosarcoma.