In prostate cancer cells, curcumin inhibits the activation of the ERK1/2/c-Myc/HIF-1α signaling axis and reduces the activity of rate-limiting enzymes such as HK1/2, PFKP, and PDH in a concentration-dependent manner, thereby blocking glycolytic metabolic flux and glucose consumption [26]. This evidence concerns the gene PDP1 and Familial prostate cancer.