INS and polycystic ovary syndrome: An analysis of three RCTs in women with polycystic ovary syndrome—PCOS (500–1500 mg/day for 6–12 weeks) revealed significant reductions in fasting glucose (MD: −2.77, 95% CI: −4.16 to −1.38), fasting insulin (MD: −1.33, 95% CI: −2.18 to −0.49) and HOMA-IR (MD: −0.32, 95% CI: −0.52 to −0.12), alongside improved lipid profiles [128].