Among the top 30 pathways ranked by p-value, eight were closely related to AD mechanisms: the Toll-like receptor signaling pathway, C-type lectin receptor signaling pathway, HIF-1 signaling pathway, TNF signaling pathway, FoxO signaling pathway, JAK–STAT signaling pathway, MAPK signaling pathway, and adipocytokine signaling pathway (Figure 5). The gene discussed is TNF; the disease is Alzheimer disease.