The final screening step (DC > 33.42857, BC > 0.012156, CC > 0.878397) resulted in 6 core genes—AKT1, STAT3, IL6, TNF, EGFR, and IL1B—forming a condensed interaction network of 6 nodes and 15 edges (Figure 3D and Table 2). The gene discussed is TNF; the disease is breast cancer.