INS and diabetes mellitus: In acute animal tests, mice administered CGA or a crude extract of CGA improved the increase in blood glucose caused by glucagon or sodium pyruvate, and in agreement with the study of Abdollahi Milad et al., CGA supplementation can improve prediabetic complications [28], including weight gain and elevated fasting blood glucose and plasma insulin levels, and these effects are related to changes in mRNA levels of important genes such as hepatic glycogen synthesis, glycogenesis, and glycolysis, suggesting that chlorogenic acid has important significance in inhibiting diabetes.