In view of recent findings about the influence of growth factors in uterine fibroids, this review aims to evaluate and provide a brief overview of VEGF and the transforming growth factor beta 3 (TGF-β3) in the fibroid pathogenesis, the role of other growth factors, risk factors, and how growth factor interactions with isoforms influence disease progression. The gene discussed is TGFB3; the disease is leiomyoma.