PDGFs and their receptors, such as PDGFRα and PDGFRβ expression, have been observed in multiple cancer types including non-small cell lung carcinoma (NSCLC), gastrointestinal stromal tumors (GIST), pancreatic carcinoma, breast and ovarian carcinomas, hepatocellular carcinoma, and diverse neuroendocrine tumors [46]. This evidence concerns the gene PDGFRA and neuroendocrine neoplasm.