In view of recent findings about the influence of growth factors in uterine fibroids, this review aims to evaluate and provide a brief overview of VEGF and the transforming growth factor beta 3 (TGF-β3) in the fibroid pathogenesis, the role of other growth factors, risk factors, and how growth factor interactions with isoforms influence disease progression. This evidence concerns the gene VEGFA and uterine corpus leiomyoma.