CD4 and neoplasm: Further analysis of specific immune cell subsets revealed a distinct pattern: DHCR24 expression was negatively correlated with the abundance of anti-tumor immune cells (e.g., CD8+ T cells, CD4+ Th1 cells) and positively correlated with pro-tumorigenic components (e.g., M2 macrophages, cancer-associated fibroblasts) (Figure 8B).