Salvianolic acid B (Sal-B), a key water-soluble compound derived from the herb Salvia miltiorrhiza (Danshen), upregulates NRF2 expression and downstream antioxidant genes while inhibiting the NF-κB inflammatory pathway, thereby counteracting UVB-induced skin aging through ROS clearance and anti-inflammatory mechanisms [97,98]. The gene discussed is NFE2L2; the disease is aging.