Splicing regulators such as SRSF1, SNW1, SNRPE, HNRNPC, EIF4A3, EFTUD2, DHX9, and DHX15 govern pre-mRNA maturation, ribonucleoprotein assembly, and alternative splicing—mechanisms frequently hijacked in colorectal, pancreatic, and renal cancers to favor oncogenic isoforms. The gene discussed is EFTUD2; the disease is renal carcinoma.