Based on co-expression network and protein–protein interaction analyses, A3C may exert tumor-suppressive effects through three mechanisms: First, it upregulates STING1 (a key protein in the cGAS-Sting pathway that regulates inflammation and immunity [29,30,31,32]) and modulates Caspase1 (involved in inflammasome activation and pyroptosis [33,34]) and its downstream inflammatory factors IL18 and IL1β (which recruit immune cells [35]). Here, APOBEC3C is linked to neoplasm.