FLT3 and IDH2 mutations are more commonly seen in KMT2A-rearranged acute myeloid leukemia (KMT2Ar AML), whereas NPM1, TP53, and myelodysplasia-related mutations are more commonly seen in KMT2A wild-type AML (KMT2Awt). Here, IDH2 is linked to acute myeloid leukemia.