GPT and chronic hepatitis B virus infection: The Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B (REACH-B) score, developed in 2011 from the untreated, non-cirrhotic Taiwanese REVEAL-HBV cohort, incorporates age, sex, ALT, hepatitis B e antigen (HBeAg) status, and HBV DNA level into a predictive model for HCC risk.