The PLAN-B model, developed using a gradient boosting machine algorithm in chronic hepatitis B cohorts, incorporates cirrhosis status, age, platelet count, entecavir or tenofovir disoproxil fumarate use, sex, ALT, HBV DNA, albumin, bilirubin, and HBeAg status, and identifies a minimal risk group with an eight-year HCC risk of less than 0.5%. The gene discussed is ALB; the disease is hepatocellular carcinoma.