The score enables clinicians to identify patients at low and high risk for HCC with high discrimination (AUC > 0.8) for HCC prediction, comparable to other AFP-inclusive models such as APA-B (which includes age, platelet count, and AFP) and REAL-B (which includes sex, age, alcohol use, diabetes, baseline cirrhosis, platelet count, and AFP) [76,88]. This evidence concerns the gene AFP and diabetes mellitus.