In a comprehensive analysis of 30 infantile (<12 months old) CNS tumors, 7/10 cases of desmoplastic infantile ganglioglioma (DIG) harbored alterations in BRAF (5 mutations, 1 duplication and 1 fusion), 1/2 cases of PXA carried the CAP-Gly domain containing linker protein 2 (CLIP2)-BRAF fusion, 1/2 cases of PA had the KIAA1549-BRAF fusion, and a single case of DLGG was BRAF V600E-mutant [55]. Here, BRAF is linked to desmoplastic infantile ganglioglioma.