myCAFs coexpress the matrix metalloproteinases MMP2 and MMP14 and secrete proangiogenic growth factors, creating an active stromal milieu that remodels pathologic tissue, stimulates tumor growth and dissemination, and facilitates tumor cell migration across ECM components such as collagen, fibronectin, and hyaluronan [67,86,87,88]. Here, FN1 is linked to neoplasm.