During tumor evolution, they can promote or inhibit tumor growth and metastasis (e.g., miR-210, miR-93-5p, miR-181d-5p), confer chemoresistance by transferring resistance-related molecules (e.g., miR-106b, miR-21, lncRNA H19, UCA1), and mediate immune evasion via PD-L1 and miR-92–driven suppression of T cells [153]. Here, CD274 is linked to neoplasm.