PDCD1 and neoplasm: These increases were also seen in the tumor periphery, with all treatment tumors exhibiting elevated CD68+ levels compared to the IgG control (IgG vs. PD1: p = 0.0035; IgG vs. PD1 + RT: p = 0.00025, PD1 vs. PD1 + RT: p = 0.00021).