AKT1 and neoplasm: Understanding ARID1A’s role is important because loss of ARID1A disrupts DNA repair, cell-cycle control, and chromatin regulation, leading to aggressive tumor progression via enhancing EMT and activating PI3K/AKT oncogenic signaling; conversely, abnormal overexpression of ARID1A may induce oxidative stress by CYP450 and initiate tumor growth.