This immune reprogramming can be mediated through sustained exposure to tumor-derived cytokines such as IL6 (interleukin-6), TNFα (tumor necrosis factor-alpha), IL1β (interleukin-1 beta), TGFB (transforming growth factor beta), chemokines, growth factors, and extracellular vesicles [10,11,12,13]. This evidence concerns the gene TNF and neoplasm.