The data shown in Figure 3C illustrate increased expression of HIF-1α in cancer cells cultured with 2-ANPC in the presence of MG-132, compared with cancer cells cultured with 2-ANPC alone, thereby suggesting rapid protein turnover in cancer cells after exposure to 2-ANPC due to increased proteasome-mediated HIF-1α degradation. The gene discussed is HIF1A; the disease is cancer.