Thus, the examination of the HIF-1-inhibitory activities of 2-ANPC, with proven cytotoxic, anti-proliferative, and anti-tumor activities, is highly attractive and, if successful, would lead to 2-aminopyrroles being considered a novel class of potent anticancer agents with a dual mode of action, effectively targeting microtubule polymerization and inhibiting HIF-1 activity. This evidence concerns the gene HIF1A and neoplasm.