TRIM63 and neoplasm: Tumor-derived extracellular vesicles (EVs) add a remote-regulation dimension: EV-miR-223-5p, exported from pancreatic ductal adenocarcinoma, targets the 3′UTR of MAFA and down-regulates METTL14, creating an m6A-deficient epigenetic environment that enhances MuRF-1 transcription and proteolysis [130,131].