Tumor-type-specific datasets support this conserved inhibitory effect: in renal cell carcinoma and multiple solid-tumor models, constitutive FGFR signaling diminishes IFN-γ-induced STAT1 phosphorylation and downstream genes such as IRF1, CXCL10, B2M, and PD-L1, while FGFR blockade reinstates this pathway [136]. This evidence concerns the gene CD274 and neoplasm.