The HGF/MET pathway is classically recognized as a primary initiator of “invasive growth” and EMT driven by stromal paracrine signaling, whereas the CXCL12/CXCR4 axis predominantly functions as a “chemotactic compass” guiding tumor cell homing to specific organs like the bone and lung [172,173]. The gene discussed is CXCR4; the disease is neoplasm.