In a study conducted on C57BL/6N mice inoculated with murine breast cancer cells E0771 (BC epithelial-like cells) and on the MDA-MB-231 cell line, PPLs demonstrated cytoplasmatic accumulation and reduced Akt phosphorylation at serine 473, leading to cell cycle arrest in the G0/G1 phase [179]. Here, AKT1 is linked to breast cancer.