For OS, ≥4 metastatic lymph nodes (HR = 4.89), the location of the primary tumor in the rectum and right colon (HR = 5.05, HR = 2.63), no chemotherapy treatment (HR = 7.36), and high-expression of p53, MDM2, and Ki-67 (HR = 0.35, HR = 2, and HR = 2.94) emerged as an independent adverse prognostic indicators. The gene discussed is MDM2; the disease is neoplasm.