Analysis of patient-specific factors did not demonstrate an association of LC with age at onset of OPD (p = 0.77), gender (p = 0.53), smoking status (p > 0.05), PD-L1 TPS (p = 0.15), and KRAS mutational status (p = 0.19) (Table 3). The gene discussed is CD274; the disease is laryngotracheoesophageal cleft.